A lineage reprogramming in which one mature somatic cell transforms into another without undergoing an intermediate pluripotent or progenitor cell type. It can occur with some lymphoid tumors, such as follicular lymphoma and chronic lymphoid leukemia/small lymphocytic leukemia (CLL/SLL), where a subsequent histiocytic sarcoma shares molecular/genetic features with the lymphoid neoplasm. Its current uses include disease modeling and drug discovery , gene therapy, and regenerative medicine .
Published in Chapter:
Mature T/NK Proliferations/Lymphomas and HL: Diagnostic Approach
Copyright: © 2024
|Pages: 32
DOI: 10.4018/978-1-6684-5818-1.ch013
Abstract
“T and NK-cell lymphoid proliferations and lymphomas” comprise nine groups with distinct cell origins, differentiation states, clinical features, localization, and cytomorphology. Most correspond to specific T or NK lineage. Still, few have a hybrid or indeterminate phenotype, including extranodal NK and T-cell lymphoma, EBV+ nodal T/NK-cell lymphoma, chronic active EBV disease, and severe mosquito bite allergy. The distinction between T- and NK cells is sometimes unclear. The main categories are Mature T-cell and NK-cell leukemias, Primary cutaneous T-cell lymphoid proliferations and lymphomas (CTCL), Intestinal T- and NK-cell lymphoid proliferations and lymphomas, Nodal T-Follicular Helper Cell Lymphomas, Peripheral T-cell lymphomas (PTCLs), EBV-related mature T-cell and NK-cell neoplasms, and Extranodal NK/T-cell lymphoma (ENKTL). HL comprises classical HL (cHL) and nodular lymphocyte predominant HL (NLPHL) subtypes.