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What is Biomarker

Tactical Sciences for Biosecurity in Animal and Plant Systems
A measurable substance in an organism whose presence is indicative of response to some phenomenon such as disease, infection, or environmental exposure.
Published in Chapter:
Training, Tests, and Tech: Deployment of Diagnostic Tools for Biosecurity
Carrie Lapaire Harmon (University of Florida, USA), Bruce L. Akey (Texas A&M Veterinary Medical Diagnostic Laboratory, USA), Francisco Manuel Ochoa-Corona (Oklahoma State University, USA), Akhilesh Ramachandran (Oklahoma State University, USA), and Poonam Sharma (Oklahoma State University, USA)
Copyright: © 2022 |Pages: 40
DOI: 10.4018/978-1-7998-7935-0.ch007
Abstract
Diagnosis of disease is a process of hypothesis, investigation, and synthesis. Regardless of whether a human, animal, or plant is afflicted, the process of diagnosis is strikingly similar. Positioned on the biosecurity continuum between surveillance and response, early and accurate diagnosis is critical to effective mitigation and management of disease. Infectious diseases have the potential to spread among animal or plant populations, jump species barriers, and result in epidemics and global pandemics. Additionally, zoonotic infectious agents can also significantly impact human health on a mass scale. It is critical that infectious diseases be identified and detected in a timely fashion to prevent spread. This chapter will delve into the resources and supporting activities for that process, demonstrated via case studies from animal and plant systems, illuminating similarities and differences in the diagnostic process tools that can be mobilized and enhanced for biosecurity.
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More Results
Systems Biology Applied to Cancer Research
By definition any bio(logical) marker like a gene or a protein. In molecular oncology, due to the complexity of cancer diseases, highly parallel techniques are needed to identify a set of biomarkers rather than a unique biomarker. Sets of biomarkers are believed to be stronger predictors since they would reflect more reliably the multidimensionality of cancer.
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Network-Driven Analysis Methods and their Application to Drug Discovery
Simple or complex measurable indicator of disease state, therapeutic efficacy or adverse effect. In the context of this article, the term is specifically used to describe molecular readouts with mechanistic relationship to the intervention.
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Current Omics Technologies in Biomarker Discovery
A characteristic that is objectively measured and evaluated as an indicator of a biological state.
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Application of Bio-Feedback in Neurodevelopmental Disorders
Biological markers are substances used as an objective indicator of a biological state.
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Study of Basic Concepts on the Development of Protein Microarray - Gene Expression Profiling: Protein Microarray
A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.
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Prototype Based Classification in Bioinformatics
Mainly in clinical research one goal of experiments is to determine patterns which are predictive for the presents or prognosis of a disease state, frequently called biomarker. Biomarkers can be single or complex (pattern) indicator variables taken from multiple measurements of a sample. The ideal biomarker has a high sensitivity, specificity and is reproducible (under standardized conditions) with respect to control experiments in other labs. Further it can be expected that the marker is vanishing or changing during a treatment of the disease.
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Personalized Medicine in the Era of Genomics
It is measurable indicator for a biological state or physiological condition
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