What is Surface Plasmon Resonance

Molecular diagnosis is based on target detection associated with many diseases and abnormalities. Common analytical techniques have disadvantages in the diagnosis. In contrast, biosensors are performed quick and selective detection of various markers. Surface plasmon resonance (SPR) biosensor allows qualitative and quantitative measurements without labelling and frequently used in medical applications. Recent developments in various emerging disciplines have allowed the design of novel bioreceptors for SPR biosensors. In recent years, the use of bioreceptors combined with nanotechnology and molecular imprinting technologies has increased in SPR instruments. Molecularly imprinted polymers (MIPs) are synthetic polymeric materials and provide specific and selective recognition sites for the target of interest. MIPs as bioreceptor show unique features compared to natural receptors. Therefore, MIP-based bioreceptors in SPR sensors have gained more attention recently. This chapter primarily focuses on the status and applications of nano-MIP-based SPR biosensors for the molecular diagnosis.