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What is Cellular Prion Proteins

Chapter 16
Principles and Clinical Interventions in Social Cognition
Membrane-bound glycoprotein that is primarily present in neurons is called cellular prion proteins, or PrPC. They are highly expressed in the central nervous system and are encoded by the PRNP gene. Numerous physiological processes, such as neuroprotection, synaptic plasticity, and cell signalling, are influenced by PrPC. PrPC is essential for preserving neuronal homeostasis in healthy circumstances. Nevertheless, under some conditions, PrPC may misfold into an aberrant conformation, resulting in the production of infectious prions. These are linked to prion illnesses including Creutzfeldt-Jakob disease and its variation.
Published in Chapter:
Social Cognitive Rehabilitation for Neurodegenerative Disorders
S. Meghana (National Institute of Advanced Studies, Bengaluru, India) and Sakshi Shishir (Christ University, India)
Copyright: © 2024 |Pages: 19
DOI: 10.4018/979-8-3693-1265-0.ch016
Abstract
In this chapter, an initial exploration of the definition and symptoms of neurodegenerative disorders will be conducted along with an in-depth analysis of their underlying neurobiological basis, shedding light on their manifestation in the brain. The central focus will then shift towards comprehending and addressing the specific social cognitive deficits associated with different types of NDs and examining the challenges posed in the realm of social cognition. Strategies and interventions specifically designed for social cognitive rehabilitation will be investigated. The chapter will encompass a discussion on the caregiver burden and effective coping strategies to alleviate the stresses faced. The primary objective of this chapter is to provide readers with a comprehensive understanding of the intricate nature of social cognitive deficits in neurodegenerative disorders and equip them with practical tools aimed at enhancing social cognition and improving the quality of life for individuals affected by these complex conditions.
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