What is Semantic Interoperability

True e-enabled collaboration has been assessed for many years. With the growing reach of companies’ business and cross-border trade, the entire ecosystem enterprises are embedded in is playing a crucial role to succeed. As ICT is a key driver for deploying true interoperability and integration among the participants of the ecosystem, actors with a lack of ICT knowledge, equipment, and implementation represent the vulnerable parts within the ecosystem. This article aims at providing an overview of challenges limiting business partners in an ecosystem to truly e-collaborate. Furthermore, it describes the key elements of e-enabled collaboration and interoperability ranging from the technical and business oriented to cross-organizational and cultural aspects.