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What is Osteoclasts-Myeloma Interaction

Chapter 12
Principles and Approaches to Diagnostic Bone Marrow Examination
Osteoclasts are recruited around MM cells in the bone marrow. They enhance MM cell growth and survival through direct cell-to-cell contact. They also produce cytokines like interleukin-6 (IL-6) and osteopontin (OPN), promoting MM cell survival. The interaction between MM cells and OCs forms a vicious cycle, exacerbating bone destruction and MM expansion. This interplay is crucial for developing targeted therapies to mitigate bone damage in multiple myeloma patients.
Published in Chapter:
Mature B Cell Lymphoproliferation and Lymphomas: Diagnostic Approach
Copyright: © 2024 |Pages: 54
DOI: 10.4018/978-1-6684-5818-1.ch012
Abstract
Most mature B cell lymphomas arise as clonal expansions corresponding to differentiation pathway stages with few exceptions. Many immunologic, toxic, and genetic factors predispose to lymphoma development. B-cell lymphomas are the most frequent types, often widely disseminated, involving the bone marrow and hemopoietic system. Many reactive conditions simulate lymphomatous infiltrates and need special diagnostic consideration, including viral and immunological reactions. The diagnosis should integrate clinicopathologic features, imaging, comprehensive hematologic examination, immunophenotyping, cytogenetics, molecular profile, and risk stratification. This comprehensive assessment also helps with treatment selection and potential targeted therapy.
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