What is Nanoengineering

Ensuring human health safety necessitates rigorous biosafety evaluations of substances and materials, particularly in the context of in-vivo exposure. Biodegradable materials, known for their natural decomposition capabilities through biological mechanisms, may exhibit toxicological profiles differing from non-biodegradable substances. Prior to their application in medical devices such as stents and implants, it is imperative to conduct thorough testing to ascertain their safety. This chapter aims to provide a comprehensive assessment of the in-vivo biosafety of various biodegradable materials. The authors employ an integrative approach, combining in-vitro ion-tolerance assays with in-vivo microanalysis techniques. This dual methodology allows for a detailed evaluation of the materials' biocompatibility and potential toxicity, particularly focusing on nanomaterial-induced toxicity in neural tissues. These findings offer critical insights into the safe application of biodegradable biomedical materials, underpinning informed decision-making in their usage for medical applications.