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What is IG Locus-Associated Translocations

Chapter 12
Principles and Approaches to Diagnostic Bone Marrow Examination
Chromosomal rearrangements involving the immunoglobulin (IG) loci, which encode the variable regions of B-cell receptors (BCRs). They juxtapose fragments of DNA that are usually located on different chromosomes, leading to altered gene expression and potential oncogenic effects. These translocations play a pivotal role in B-cell malignancies by altering gene expression and contributing to tumor development. Understanding their mechanisms can also guide targeted therapies and improve patient outcomes. They are a hallmark of many B-cell malignancies.
Published in Chapter:
Mature B Cell Lymphoproliferation and Lymphomas: Diagnostic Approach
Copyright: © 2024 |Pages: 54
DOI: 10.4018/978-1-6684-5818-1.ch012
Abstract
Most mature B cell lymphomas arise as clonal expansions corresponding to differentiation pathway stages with few exceptions. Many immunologic, toxic, and genetic factors predispose to lymphoma development. B-cell lymphomas are the most frequent types, often widely disseminated, involving the bone marrow and hemopoietic system. Many reactive conditions simulate lymphomatous infiltrates and need special diagnostic consideration, including viral and immunological reactions. The diagnosis should integrate clinicopathologic features, imaging, comprehensive hematologic examination, immunophenotyping, cytogenetics, molecular profile, and risk stratification. This comprehensive assessment also helps with treatment selection and potential targeted therapy.
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