What is IG Loci Promiscuity

Most mature B cell lymphomas arise as clonal expansions corresponding to differentiation pathway stages with few exceptions. Many immunologic, toxic, and genetic factors predispose to lymphoma development. B-cell lymphomas are the most frequent types, often widely disseminated, involving the bone marrow and hemopoietic system. Many reactive conditions simulate lymphomatous infiltrates and need special diagnostic consideration, including viral and immunological reactions. The diagnosis should integrate clinicopathologic features, imaging, comprehensive hematologic examination, immunophenotyping, cytogenetics, molecular profile, and risk stratification. This comprehensive assessment also helps with treatment selection and potential targeted therapy.