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What is Gene regulatory network (GRN)

Handbook of Research on Design, Control, and Modeling of Swarm Robotics
Depicts a collection of DNA segments in a cell that interact with each other (indirectly through their RNA and protein expression products) and with other substances in the cell, thereby governing the rates at which genes in the network are transcribed into messenger RNA (mRNA).
Published in Chapter:
Adaptive Self-Organizing Organisms Using A Bio-Inspired Gene Regulatory Network Controller: For the Aggregation of Evolutionary Robots under a Changing Environment
Yao Yao (Ghent University, Belgium), Kathleen Marchal (Ghent University, Belgium), and Yves Van de Peer (Ghent University, Belgium)
DOI: 10.4018/978-1-4666-9572-6.ch003
Abstract
This work has explored the adaptive potential of simulated swarm robots that contain a genomic encoding of a bio-inspired gene regulatory network (GRN). An artificial genome is combined with a flexible agent-based system, representing the activated part of the regulatory network that transduces environmental cues into phenotypic behavior. Using an Alife simulation framework that mimics a changing environment, we have shown that separating the static from the conditionally active part of the network contributes to a better adaptive behavior. This chapter describes the biologically inspired concept of GRNs to develop a distributed robot self-organizing approach. In particular, it shows that by using this approach, multiple swarm robots can aggregate to form a robotic organism that can adapt its configuration as a response to a dynamically changing environment. In addition, through the comparison of several different simulation experiments, the results illustrate the impact of evolutionary operators such as mutations and duplications on improving the adaptability of organisms.
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More Results
A Bayes Regularized Ordinary Differential Equation Model for the Inference of Gene Regulatory Networks
Here a directed graph G(V,E) with n nodes corresponding to n genes in the network. An edge from node j to node i indicates that gene product j has an influence on the expression rate of gene i. This influence is assumed to be either activating or inhibiting. The dynamics of the system is described by ordinary differential equations.
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Modelling Gene Regulatory Networks Using Computational Intelligence Techniques
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