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What is DNA Repair

Chapter 21
Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications
Refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not take effect, “Irreparable DNA Damage” can occur, including double-strand breaks and DNA cross linkages
Published in Chapter:
Dynamic Modeling and Parameter Identification for Biological Networks: Application to the DNA Damage and Repair Processes
Fortunato Bianconi (University of Perugia, Italy), Gabriele Lillacci (University of Perugia, Italy), and Paolo Valigi (University of Perugia, Italy)
Copyright: © 2011 |Pages: 33
DOI: 10.4018/978-1-60960-491-2.ch021
Abstract
Then, two different parameter identification techniques are presented for the proposed models. One is based on a least squares procedure, which treats the signals provided by a high gain observer; the other one is based on a Mixed Extended Kalman Filter. Prior to the estimation phase, identifiability and sensitivity analyses are used to determine which parameters can be and/or should be estimated. The procedures are tested and compared by means of data obtained by in silico experiments.
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