A Machine Learning-Based Predictive Model for Drug Sensitivity in Breast Cancer Using Gene Expression Data

A Machine Learning-Based Predictive Model for Drug Sensitivity in Breast Cancer Using Gene Expression Data

DOI: 10.4018/979-8-3693-1662-7.ch008
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Abstract

Through the combination of tool learning patterns, this study offers a novel strategy for personalised treatment for the majority of breast malignancies. The authors used a carefully assembled dataset that included 3444 cases of drug management data, affected person profiles, diagnostic scans, and scientific reviews to train artificial neural networks (ANN), support vector machines (SVM), decision trees (DT), and random forests (RF) for drug sensitivity prediction modelling. While SVM demonstrated its capacity to handle high-dimensional statistics with an accuracy of 96.5%, the artificial neural network (ANN) exhibited remarkable versatility, achieving a commendable accuracy rate of 97.5%. The interpretability inherent in decision trees (DT) and the combined energy of random forests (RF) added crucial elements to the multifaceted methodology. The outcome of the research underscores that the proposed machine learning model stands out with the highest efficacy in predicting the most accurate drug for a given patient.
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Introduction

Breast cancers is the long-term a worldwide health conflict, Machine learning techniques models are used recently for diagnostic and medicinal medicine (AlZubi et al., 2021; Cheng et al., 2022). In this strategy, the 4 different machine learning models are used in this research to accurately predict the proper drug for the treatment of cancer. In this research four different machine learning model are used and they are Artificial Neural Networks (ANN), Support Vector Machines (SVM), Decision Trees (DT), and Random Forests (RF). Each ML model are trained datasets containing person profiles, diagnostic scans, clinical data, and medicinal medication management information (Maione et al., 2019; Pathak & Kulkarni, 2015).

The previous research shows that the gaining know-how of in breast biggest cancers study emphasizes the expanding effectiveness of records-driven tactics in improving diagnostic accuracy and mending results. Numerous investigations have confirmed the usefulness of Artificial Neural Networks (ANN) in know-how complicated designs inside gene expression records, offering considerable insights into sickness improvement and medication response (Tuli et al., 2020; Zamani et al., 2022). The flexibility of ANN to non-linear interactions and its desire to explore hierarchical representations make it an appealing instrument for tailor-made predictive modeling (Berghout et al., 2022).

Support Vector Machines (SVM) have accomplished popularity for his or her competency in handling immoderate-dimensional facts and discovering maximal simplest hyperplanes for kind assignments. In the state of affairs of breast biggest cancers, SVM has confirmed aptitude in recognising dispersed styles among heterogeneous data, leading to extra appropriate estimations of medication responses (Goswami, Sharma, Mathuku, Gangadharan, Yadav, Sahu, Pradhan, Singh, & Imran, 2022; Goswami, Sharma, Mathuku, Gangadharan, Yadav, Sahu, Pradhan, Singh, & Imran, 2022). The research moreover stresses the transparency and interpretability of choice Trees (DT), dropping sunshine on essential preference components and altering skills within the prediction technique. This interpretability will become vital in detecting the motivation within the rear of medication sensitivity forecasts and making use of medical preference-making (Olalere & Olanrewaju, 2022; Rabbani et al., 2022).

Ensemble gaining knowledge of techniques, demonstrated by way of Random Forests (RF), have showed extraordinary accomplishment in increasing predictive accuracy via aggregating forecasts from a pair of choice bushes. The strength of RF resides in its capacity to capture intricate connections across capabilities, producing a powerful and reliable prediction model. Integrating those many machine learning knowledge of tactics into breast cancer research supplies a comprehensive aspect, addressing the problems offered by means of the heterogeneity of the ailment (Arya et al., 2023; Sellamuthu et al., 2023).

While distinct study have studied the usefulness of those styles in isolation, there's a compelling want for complete research that contrasts and incorporates the benefits of ANN, SVM, DT, and RF within the unique scenario of breast most cancers therapy. This study seeks to bridge this gap by means of doing a radical investigation into the predictive skills of every model, offering a sophisticated comprehension in their man or woman contributions and cumulative influence on individualized medication sensitivity forecasts for breast cancer sufferers (Indoria et al., 2023; Mishra et al., 2023).

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