Article Preview
Top1. Introduction
The influence of various nanomaterials on the everyday life gradually increase owing to their high functional potential be very useful materials for different applications (Vanić and Škalko-Basnet, 2013; Ma et al., 2013; Singh and Gupta, 2014; Melagraki and Afantitis, 2014; Panneerselvam and Choi, 2014; Potrč et al., 2015; Sauer et al., 2015; Speck-Planche et al., 2015). However, a tool to risk assessment for nanomaterials similar to quantitative structure – property /activity relationships (QSPRs/QSARs) (Toropova et al., 2012; Yilmaz et al., 2015) as research field is in an initial phase of the development (Muthu, 2012; Oksel et al., 2015). The solution of this task for regulatory purposes in the case of nanomaterials involved in the agriculture, food, cosmetics, drug discovery, etc. needs to be reached in the near future (Arts et al., 2014; Arts et al., 2015; Filon et al., 2015; Amenta et al., 2015).
In general, different measures of danger acting of nanomaterials upon cells are known (Long et al., 2009; Prabhakar et al., 2012; Diez-Ortiz et al., 2015; Toropova et al., 2015a; Hadrup et al., 2015). In particular, the level of malondialdehyde (MDA) in wet tissue of different organs is considered as a measure of toxic effect of nanomaterials (Long et al., 2009; Prabhakar et al., 2012).
Attempts which are aimed to build up models for such acting of nanomaterials using the traditional QSPR/QSAR approaches (De Abrew et al., 2015), as rule, are impossible excepting the cases of acting of small molecules together with a nanomaterial (Fourches et al., 2010; Toropov et al., 2013).
In the case of traditional materials where the molecular structure represented by SMILES is available to mathematical and computational analyses, the QSPR/QSAR is a tool to more or less satisfactory prediction of different endpoints (Veselinović et al., 2013; Achary, 2014a, 2014b; Comelli et al., 2014; Nesmerak et al., 2014; Worachartcheewan et al., 2014; Toropova and Toropov, 2014; Veselinović et al., 2015).
A possible way to build up such models can be expressed by paradigm: “Endpoint = f(SMILES)”. In the case of nanomaterials where weak variation of molecular structure accompanied by intensive variation of conditions more appropriate paradigm is “Endpoint = f(Eclectic data)”.
The quasi-SMILES can be the representation of eclectic data (Toropov and Toropova, 2015). The quasi-SMILES are analogies of traditional SMILES, but symbols involved in the quasi-SMILES are representations of features and/or conditions that are not representation of features of the molecular architecture only. (Toropova and Toropov, 2013; Toropov and Toropova, 2014; Toropova et al., 2015b).
The aim of this work is to build up models for level of MDA in wet tissue of different organs of rat under different action of Al2O3 nanoparticles.