SCND is one of the most vital planning problems in supply chain management (SCM). Currently, design decisions should be practicable enough to function under the complex, dynamic, uncertain and robust business environments for many decades. Due to the complexity of supply chain networks in today’s business environment, it is significant to consider several planning decisions along with the classical location-allocation decisions such as number of proposed facility locations, influence area and facility location allocation to achieve an integrated system. Network design is the basis for the efficient operation of supply chain and consequently one of the most important problems a supply chain manager is to solve. This paper conducts a real-life case-based modeling to investigate a SCND of milk product under preservation technology encompassing economic objective by developing a customized mathematical model for a leading milk producing organization in Odisha. The models are formulated and solved by using piecewise nonlinear optimization.