Emerging Pandemic COVID 19 vs. SARS-COV-1

Emerging Pandemic COVID 19 vs. SARS-COV-1

Sunanda Dixit, Mahalakshmi J., Riya Mahesh
DOI: 10.4018/IJARPHM.2022010105
OnDemand:
(Individual Articles)
Available
$37.50
No Current Special Offers
TOTAL SAVINGS: $37.50

Abstract

Rising threat of the global pandemic COVID 19 has become the major cause of concern among nations worldwide. The appalling pandemic has aggravated the global health of people making normal life come to a virtual standstill. The purpose of this study is to investigate and compare the similarities and differences between the previous global pandemic outbreak SARS-COV-1 with that of COVID 19. It makes use of a bioinformatic approach to analyze why COVID 19 has made situations uncontrollable as opposed to that of SARS-COV-1 although both belong to the same coronavirus family. Discusses about the recent clinical trials that are being conducted to evaluate potential therapeutics to combat the deadly pandemic. There is currently no available vaccine for COVID 19. E The current status of COVID 19 research stands progressive in various areas of knowledge. Further studies based on emerging evidences are required to produce drugs which can slow down disease progression and improve survival.
Article Preview
Top

Introduction

Does the COVID-19 named as SARS-CoV-2 (Gorbalenya, A.E., Baker, S.C., Baric, R.S., 2020), pandemic stand as a global-wide curse for humanity? Spike in the number of positive COVID-19 cases and fatalities day after day have brought this fact to the limelight. As of October 23rd, 2020, the outbreak has resulted in 41.7 M, confirmed cases with 1.14M, deaths with recovered cases amounting to 28.3M (John Hopkins Corona Virus Resource Center, daily online updates October 23rd 2020). A similar outbreak was witnessed by the world in 2003 called the Severe Acute Respiratory Syndrome (SARS-CoV-1). One of the most striking similarity is that the virus causing SARS-CoV-1 has 86% genome similarity with that of COVID-19. This fact has been substantiated based on pathogenetic analysis below. Contact tracing was really effective with SARS-CoV-1 largely because symptoms were severe and therefore easier to identify and contain. It lacked the competence to fight the human community which eventually led to its downfall. This doesn’t seem to be the case of COVID-19, which seems to have the ability to spread and survive in the human body. Although the latter’s death rate was higher, COVID-19 has led to more fatalities, more economic repercussions and more social repercussions. Moreover, claims that the coronavirus is being used as a manipulated biological warfare weapon has been storming the Internet. However, this claim is unsubstantiated and scientific evidences have proved that the virus arose naturally.

SARS (Severe Acute Respiratory Syndrome)

Severe acute respiratory syndrome (SARS-COV-1) is a viral respiratory disease caused by the SARS coronavirus. The global spread of the disease had proceeded with such an accelerated speed that hospitals and medical centers witnessed teeming scenarios in a matter of weeks. As of April 14, 2003, a total of 3,169 cases had been reported from more than 20 countries (Shiing-Jer Twu, Tzay-Jinn Chen, 2003)

The first recognized SARS-CoV-1 patient was a 54-year-old businessman who travelled to Guangdong Province, Southern China, on February 5, 2003, and returned to Taipei via Hong Kong on February 21 (WHO,2002). The illnesses in the family members were confirmed by Reverse Transcription Polymerase chain reaction (RT-PCR) testing which was found to be associated with the SARS-COV-1 coronavirus. The doctor who dealt with the man’s diagnosis reported being equipped with utmost safety standards to minimize exposure to the deadly virus had also contracted the disease overtime. His illness with symptoms that met the criteria for a probable SARS-CoV-1 case was confirmed by laboratory testing through RT-PCR.

The virus which is potentially assumed to be airborne, spread through close human contact via respiratory droplets as the medium. These droplets are absorbed by the body through mucous membranes of the mouth, nose and eyes. SARS-CoV-1 is categorized as a zoonotic disease which implies that the virus has originated from a wild animal which has later been passed on to human beings. In close comparison to COVID-19, symptoms of a person who had tested positive for SARS-CoV-1 included rise in body temperature, dry cough and shortness of breath which occurred 2-7 days after being exposed to the virus. SARS-CoV-1 was considered a reportable disease (Clinical Guidance on the Identification and Evaluation of Possible SARS-CoV Disease among Persons Presenting with Community-Acquired Illness, version 2, 2004). No vaccine, drug or antibiotic proved to be effective against the virus. The World Health Organization (WHO) meted out certain barrier techniques and isolation measures to curb the spread of the virus to a larger extent.

Top

Measures

On perceiving the first positive SARS-CoV-1 case, Taiwan moved to take up stringent measures and isolate all suspected case-patients in negatively pressurized isolation rooms as a part of its early attempt to prevent transference and equipped all healthcare personnel with intensified protection. The specifically designed isolation rooms were pumped up with High Efficiency Particulate Air, negative pressure under constant electronic monitoring, separate bathroom, and antechamber in order to separate the SARS-CoV-1 patient from the rest of the hospital.

Complete Article List

Search this Journal:
Reset
Volume 9: 1 Issue (2024)
Volume 8: 1 Issue (2023)
Volume 7: 2 Issues (2022): 1 Released, 1 Forthcoming
Volume 6: 2 Issues (2021)
Volume 5: 2 Issues (2020)
Volume 4: 2 Issues (2019)
View Complete Journal Contents Listing