Bioinformatics and Patient Survival Analysis of Digestive Tract Tumor Marker NCAPG Based on Public Medical Databases

Literature Review

In recent years, the morbidity and mortality of digestive tract tumors remain high in China. These tumors have become a “malignant tumor” that seriously endangers human health. Despite the continuous improvement of surgical treatment, radiotherapy, and chemotherapy, the overall survival rate is still not optimistic. Therefore, searching for novel biomarkers that acts as key molecules and targets in the development of gastrointestinal tumors can provide suggestions for determining treatment plans and predicting prognosis, further explore new drug targets, and provide theoretical and experimental bases for the development of targeted therapies (Jager et al., 2000; García-Barrios,2021). The NCAPG protein is one of the subunits of the concentrate I complex of mitogen-associated chromosomal protein concentrate and is involved in the concentration and stabilization of mitosis and meiosis (Lam, Peterson, Yeung, & Lavoie, 2006). Studies showed that the NCAPG protein affects a variety of human tumors (Pan et al., 2019). In addition, the knockdown of NCAPG expression can promote cell apoptosis and reduce cell migration ability and is significantly correlated with prognosis (Arai et al., 2018; Mavrinac, M.,2022), thus becoming a tumor marker for liver cancer, thyroid cancer, and many other tumor diseases (Pan et al., 2019; Zhang et al., 2018; Sanchez-Carmona,2021). However, the expression and importance of the NCAPG protein in gastrointestinal tumors have not been fully recognized.