Automation of Intraoperative Analysis of the Indicators of the Inflammatory Response of Neurosurgical Patients Undergoing Brain Tumor Removal: Information Processing, Analysis, Prognosis

Subject Of The Study

There is a certain set of body reactions in which the functional state called the “surgical stage of anesthesia” is reflected and to which the anesthesiologist most often draws attention and tries to correct. These are indicators of systemic hemodynamics, changes in spontaneous and induced bioelectric activity of the brain, deviations in the level of various hormones and other biologically active substances in the blood.

In neurosurgery, the concept of the adequacy of anesthesia is interpreted more broadly. So, the criteria of adequacy in neuroanesthesiology, depending on the stage of the operation, can be: before decompression of the brain - maintaining perfusion pressure; after decompression - preservation of elasticity, suppleness of the brain, assessment and the maximum possible limitation of centrogenic reactions; at the stage of removal of the tumor and hemostasis - normal indicators of vascular-platelet and coagulation hemostasis in the wound. In addition, an adequate anesthetic benefit is the key to a smooth, harmonious exit of the patient from the anesthetized state. In the postoperative period after surgery on the brain, the clinical manifestations of inadequacy of anesthesia can be: excessive inhibition of central nervous system functions, multiple organ dysfunction. Apparently, an overly expressed systemic inflammatory response may be the background, and in some cases, the main cause of this symptomatology. For cognitive impairment, this relationship is well established (Sokolov, Lesteva & Musin, 2014).